Immune activation research
Molecular triggers of allergy and autoimmunity
The prevalence of allergic and autoimmune disease is increasing due to environmental factors that remain largely undefined. We have shown that most non-enzymatic protein adducts have little impact on the adaptive immune response, whereas others - particularly aldehydic adducts - have potent immune activating properties resulting in robust B cell responses against otherwise innocuous or self antigens. We are currently exploring the mechanism of action of aldehyde-mediated immune activation using biochemical and in vitro and in vivo immunological approaches.